Iris Valeria Rivera-Flores

Abstract The MutSL mismatch repair (MMR) system in bacteria and eukaryotes correct mismatches made at the replication fork to maintain genome stability. A novel MMR system is represented by the EndoMS/NucS endonuclease from actinobacterium Corynebacterium glutamicum, which recognizes mismatched substrates in vitro and creates dsDNA breaks at the mismatch. In this report, a genetic analysis shows that an M.

Abstract The MutSL mismatch repair system in bacteria and eukaryotes correct mismatches made at the replication fork to maintain genome stability. Despite lacking the mutSL genes, most actinobacterial species, including Mycobacterium tuberculosis, exhibit spontaneous mutation rates similar to MutSL-bearing bacteria, suggesting the existence of an alternative mismatch repair (MMR) system.