Iris Z. Jaffe
Cambridge
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Articles by Iris Z. Jaffe
Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease?
Abstract The physiology of lipid droplets (LDs) has been most extensively characterized in adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to changing levels of triglycerides. In recent issues of the JCI, two independent papers highlight a direct role of endothelial LDs in the genesis of hypertension and atherosclerosis in rodent models. Kim et al.
The Mineralocorticoid Receptor in the Vasculature: Friend or Foe?
Abstract Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data demonstrate that endothelial and smooth muscle cell MRs contribute to cardiovascular disease in response to risk factors (aging, obesity, hypertension, atherosclerosis) by inducing vasoconstriction, vascular remodeling, inflammation, and oxidative stress.
Histone Acetyltransferases in Smooth Muscle Cell Phenotype Switching: Redundant No Longer
Originally publishedhttps://doi.org/10.1161/CIRCULATIONAHA.122.060363Circulation. 2022;145:1738–1740 Footnotes References 1. Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, . Histone acetyltransferases p300 and CBP coordinate distinct chromatin remodeling programs in vascular smooth muscle plasticity.Circulation. 2022; 145:1720–1737. doi: 10.1161/CIRCULATIONAHA.121.057599LinkGoogle Scholar 2. Kingston RE .
Response by Good et al to Letter Regarding Article, “Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone”
In our recent publication, we reported the discovery that spironolactone—an antihypertensive—is also a new Panx1 (pannexin 1) inhibitor. In addition, we found that spironolactone interferes with α1AR (α1 adrenoceptor)-mediated vasoconstriction of resistance vessels and acutely lowers blood pressure in mice; importantly, these effects require Panx1 channel expression in vascular smooth muscle cells but are independent of the MR (mineralocorticoid receptor)—the traditional target of spironolactone.
30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The role of the mineralocorticoid receptor in the vasculature
Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that MR is expressed in extra-renal tissues, including the cardiovascular system, where it is expressed in all cells of the vasculature. Understanding the role of MR in the vasculature has been of particular interest as clinical trials show that MR antagonism improves cardiovascular outcomes out of proportion to changes in blood pressure.
The Anti-artist-statement Statement
I hate artist statements. Really, I do. As an artist, they are almost always awkward and painful to write, and as a viewer they are similarly painful and uninformative to read.
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