Isaac Alexander Chaim on Muck Rack

Isaac Alexander Chaim

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Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

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By Carrie M. Margulies, Isaac Alexander Chaim, Aprotim Mazumder, June Criscione
| PLOS
Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a multi-enzyme pathway initiated by the alkyladenine DNA glycosylase (Aag, also known as Mpg).
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