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Isabel K. Barter on Muck Rack

Isabel K. Barter

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ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis - Nature Communications

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By Julia Leodolter, Matthew McNeil, Sabryna Junker, Gregory Cook, Tim Clausen, Warwick J. Britton, Mark Larance, Isabel K. Barter
| Nature Verified
Abstract Targeting the protein quality control system in Mycobacterium tuberculosis represents a promising and underexplored opportunity for antibiotic development. The ClpC1:ClpP1P2 protease is an essential component of the system that mediates both regulatory and stress-related protein degradation.
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