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Isabela Rivera Paz on Muck Rack

Isabela Rivera Paz

As seen in: Nature
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Articles

Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

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By Yuan Hou, Yichen Li, Pengyue Zhang, Noah Lorincz-Comi, Dhruv Gohel, Fan Fan, Yunguang Qiu, Jun Yang, Xin McRae Chen, Wenqiang Song, Xiaoyu Yang, Zhibing Tan, Zhigang Liu, Xing Fang, William Martin, Yayan Feng, Yadi Zhou, Jielin Xu, Lijun Dou, Huawei Zhang, Sung Hee Hwang, Richard J. Roman, Lynn Bekris, Ehud Karavani, Michael M Danziger, Michal Rosen-Zvi, Jonathan Haines, Haiyuan Yu, Bruce D. Hammock, James B. Leverenz, Andrew Pieper, Jeffrey Cummings, Feixiong Cheng, Isabela Rivera Paz, Jena’ N. Mazique, Tousi Babak
| Nature Verified
Abstract Despite prolific genomic data from individuals with Alzheimer’s disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of European ancestry and 7 for African ancestry. This included epoxide hydrolase 2 (EPHX2), for which we identified a protective missense variant (p.Arg287Gln).
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