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Isabelle Lebars on Muck Rack

Isabelle Lebars

As seen in: Frontiers, BioRxiv
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Articles

Ultrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitors

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By Claire Husser, Isabelle Lebars, Janis Hoetzel, Roger Cubi
| BioRxiv
Abstract Enzymes are instrumental to life and key actors of pathologies, making them relevant drug targets. Most enzyme inhibitors consist of small molecules. Although efficient, their development is long, costly and can come with unwanted off-targeting. Substantial gain in specificity and discovery efficiency is possible using biologicals. Best exemplified by antibodies, these drugs derived from living systems display high specificity and their development is eased by harnessing natural evolution.
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Progress in 7SK ribonucleoprotein structural biology

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By Loïc Salmon, Aditi Borkar, Isabelle Lebars
| Frontiers
Momodou B. Camara1, Amr M. Sobeh1 and Catherine D. Eichhorn1,2* 1Department of Chemistry, University of Nebraska, Lincoln, NE, United States 2Nebraska Center for Integrated Biomolecular Communication, Lincoln, NE, United States The 7SK ribonucleoprotein (RNP) is a dynamic and multifunctional regulator of RNA Polymerase II (RNAPII) transcription in metazoa.
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