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Highlights • The immunoglobulin superfamily (IgSF) interactome identifies over 500 receptor pairs • The IgSF interactome reveals receptor-ligand communities dysregulated in cancer • More than 60 receptor-ligand pairs confirmed using orthogonal methods • Interacting protein signatures are correlated with clinical outcome Summary Cell surface receptors and their interactions play a central role in physiological and pathological signaling.
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