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Ishfaq Ahamd Pandith on Muck Rack

Ishfaq Ahamd Pandith

As seen in: BioRxiv
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Articles

Nuclear myosin I mediates genomic clustering of estrogen receptor-α without affecting ligand-induced transcriptional robustness

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By Rajat Mann, Deepanshu Soota, Sudha Swaminathan, Ishfaq Ahamd Pandith
| BioRxiv
Abstract Ligand-induced transcriptional responses are rapid and robust. Estrogen, one such ligand, exerts its rapid effects through the steroid hormone receptor estrogen receptor-alpha (ERα). Upon stimulation, ERα binds to clustered enhancers to drive target gene expression. Here, we identify nuclear myosin 1 (NM1/Myo1c) as a positive regulator of ERα clustering on enhancers, promoting condensate formation on chromatin.
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