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Ismael Varela

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Articles

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity - Nature Communications

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By Daliya Kancheva, Mark Gontsarik, Ismael Varela, Raymond M. Schiffelers, Sofie Deschoemaeker, Elisabeth Knetemann, Lize Allonsius, Alícia Gordún Peiró
| Nature Verified
Abstract Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxicities. Here, we develop and employ lipid-based nanoparticles (LNPs) to intratumorally deliver an mRNA mixture encoding the cytokines interleukin (IL)−21 and IL-7 and the immunostimulatory molecule 4-1BB ligand (Triplet LNP).
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