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Articles

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling - Nature Immunology

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By ismail can, Bin Fang, Tae Hyun Hwang, Anders Berglund, Virginia Shapiro, Jose R. Conejo-Garcia, José Conejo-Garcia
| Nature Verified
Abstract T cell receptor (TCR) signaling is precisely tuned to prevent self-reactivity while allowing protective immunity. Here we found that acetylation modulated TCR signaling. The loss of SIRT2 deacetylase activity in T cells led to amplified calcium mobilization and phosphorylation of key proximal TCR molecules in naive T cells and reversed dampened TCR signaling in anergic T cells.
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The protective effects of a single dose myricetin application on CLP-induced rat sepsis model by analyzing some immune mechanisms

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By ismail can, Ali Guraslan, Omer Faruk Baser, Gulfem Nur Yıldız
| Taylor & Francis Online
Advanced search Immunopharmacology and Immunotoxicology Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/08923973.2025.2469227?needAccess=true Abstract Introduction In this study, our aim was to investigate the protective effects of myricetin (single dose–100 mg/kg) on CLP-induced rat sepsis model by analyzing some immune mechanisms including inflammation and oxidative stress...
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XPoint: A Self-Supervised Visual-State-Space based Architecture for Multispectral Image Registration

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By ismail can
| arXiv
[Submitted on 11 Nov 2024] Title:XPoint: A Self-Supervised Visual-State-Space based Architecture for Multispectral Image Registration View a PDF of the paper titled XPoint: A Self-Supervised Visual-State-Space based Architecture for Multispectral Image Registration, by Ismail Can Yagmur and 2 other authors View PDF HTML (experimental) Abstract:Accurate multispectral image matching presents significant challenges due to non-linear intensity variations across spectral modalities, extreme...
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