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Itys Comet

As seen in: Wiley Online Library, Cell Press
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Articles by Itys Comet

Cover Feature: Discovery of NSD2‐Degraders from Novel and Selective DEL Hits (ChemBioChem 24/2023)

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By Jan Andersson, Jesper Frank Christensen, Daniela Kleine-Kohlbrecher, Itys Comet
| Wiley Online Library Verified
Dr. Jonatan Fullerton Støier University of Copenhagen, Biotech Research & Innovation Centre (BRIC), Ole Maaløes Vej 5, 2200 Copenhagen, Denmark Bioorigin Aps, Ole Maaløes Vej 3, 2200 Copenhagen, Denmark Search for more papers by this author
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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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By William L. Garland, Biotech Research, Mengjun Wu, Itys Comet
| Cell Press Verified
Highlights • Depletion of ZFC3H1 in mouse ESCs results in differentiation defects • PRC2 target genes are deregulated in Zfc3h1−/− cells • Chromatin binding of PRC2 and H3K27me3 is reduced in Zfc3h1−/− cells • Increased binding of RNA impairs PRC2 complex stability Summary Pluripotent embryonic stem cells (ESCs) constitute an essential cellular niche sustained by epigenomic and transcriptional regulation. Any role of post-transcriptional processes remains less explored.
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