Itzia Jimenez-Ferrer on Muck Rack

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Articles

MHC class II transactivator effects on local and systemic immune responses in an α-synuclein seeded rat model for Parkinson's disease

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By Itzia Jimenez-Ferrer, Kathleen Grabert, Lautaro Belfiori, Filip Fredlund
| biorxiv.org
Abstract BACKGROUND: Parkinson's disease (PD) is characterized by alpha-synuclein (α-Syn) pathology, neurodegeneration and neuroinflammation. HLA variants associated with PD and α-Syn specific circulating CD4+ T lymphocytes in PD patients highlight the importance of antigen presentation in PD etiology. The class II transactivator (CIITA) is the major regulator of MHCII expression.
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Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson's Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic Neurodegeneration

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By Itzia Jimenez-Ferrer, Filip Backstrom, Alfredo Dueñas Rey, Dorottya Maria Ralbovszki
| biorxiv.org
New Results doi: https://doi.org/10.1101/2023.03.22.533733 Abstract Engrailed 1 (EN1) is a conserved transcription factor essential for programming, survival, and maintenance of midbrain dopaminergic neurons. En1-hemizygosity (En1+/-) leads to a spontaneous Parkinson's disease-like (PD-like) progressive nigrostriatal degeneration as well as motor impairment and depressive-like behavior in SwissOF1 (OF1-En1+/-) mice. This phenotype is absent in C57Bl/6j (C57-En1+/-) mice.
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The MHC class II transactivator affects local and systemic immune responses in an α-synuclein seeded rat model for Parkinson's disease

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By Kathleen Grabert, Filip Backstrom, Itzia Jimenez-Ferrer, Lautaro Belfiori
| biorxiv.org
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