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Ivan Lombardi on Muck Rack

Ivan Lombardi

As seen in: Nature, Taylor & Francis Online, BioRxiv
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Articles

Recent therapeutic advances in the treatment and management of amyotrophic lateral sclerosis: the era of regenerative medicine

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By Fabiola De Marchi, Ivan Lombardi, Alessandro Bombaci, Luca Diamanti
| Taylor & Francis Online
ABSTRACT Introduction Despite decades of research, effective disease-modifying treatments for Amyotrophic Lateral Sclerosis (ALS) remain scarce, with riluzole and edaravone offering only limited benefits. The emergence of regenerative medicine, including stem cell therapy, gene-based interventions, and bioengineering strategies, presents a new frontier for ALS treatment.
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Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family - Cell Death & Disease

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By Jessica Rosati, Maurizio Gelati, Ivan Lombardi, Edvige Vulcano, Tarja Malm, Sohvi Ohtonen, Elisa Perciballi, Mario Sabatelli, Paola Fusi
| Nature Verified
Abstract Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease, causing degeneration of motor neurons, paralysis, and death. About 5–10% of cases are associated with gene mutations inherited from a family member (fALS).
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Challenges and promises in optimising a non-clinical protocol of intracerebroventricular human neural stem cell transplantation in ALS

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By Ivan Lombardi, Clelia Ferrero, Edvige Vulcano, Daniela Maria Rasa'
| BioRxiv
Abstract Background and aims: Neural stem cell (NSC) transplantation holds promising therapeutic potential for neurodegenerative disorders like amyotrophic lateral sclerosis (ALS). However, pre-clinical studies and early-phase clinical trials have faced challenges hindering the effective clinical translation of this approach.
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