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Cell line-specific modulation of colorectal cancer cell behavior following SGLT2 inhibition via empagliflozin
Abstract Colorectal cancer (CRC) is a major global health problem, with type 2 diabetes mellitus (T2DM) and obesity among its significant risk factors. Empagliflozin (EMPA), a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor widely used in the treatment of T2DM, has also demonstrated potential anticancer effects. However, reports of possible adverse effects in certain oncological contexts have raised concerns.
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