Ivo Schirmeister on Muck Rack

Ivo Schirmeister

As seen in: eLife
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Articles

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

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By Carolin Gerke, Liane Bauersfeld, Ivo Schirmeister, Chiara Noemi-Marie Mireisz
| eLife
The unexpected finding that US10 associates selectively with HLA-C and -G in their β2m-dimerized form suggests that US10 has evolved an independent molecular targeting strategy for HLA-C and -G. This prominent interaction could explain why downregulation of HLA-C allotypes did not correlate with their level of tapasin dependency. Still, whether tapasin is involved as a co-factor in retention and accumulation of peptide-loaded HLA-C in the ER needs clarification.
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