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Ivy Sebastian

As seen in: BioRxiv

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Articles

Overcoming lentiviral delivery limitations in hard-to-transduce suspension cells for genome-wide CRISPR screening

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By Antonino Napoleone, Ivy Sebastian, Federico De Marco, Alexander Karl Molin
| BioRxiv
Abstract Lentiviral vectors are a cornerstone delivery modality of biomedical research, renowned for their ability to stably integrate genetic material into the host genome, enabling sustained transgene expression and long-term genetic manipulation.
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A genome-scale CRISPR deletion screen in Chinese Hamster Ovary cells reveals essential regions of the coding and non-coding genome

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By Nina Bydlinski, Federico De Marco, Ivy Sebastian, Antonino Napoleone
| BioRxiv
Abstract The biopharmaceutical sector relies on CHO cells to investigate biological processes and as the preferred host for production of biotherapeutics. Simultaneously, advancements in CHO cell genome assembly have provided insights for developing sophisticated genetic engineering strategies.
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