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J Barney Bryson on Muck Rack

J Barney Bryson

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Articles

An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

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By Dai Jiang, Andreas Demosthenous, J Barney Bryson, Alexandra Kourgiantaki
| eLife
eLife assessment This fundamental study presents a valuable method to restore muscle innervations in ALS mouse models using optogenetics. It is convincing that embryonic stem cell derived motor neurons can be transplanted into and applied to reinnervate the muscles in an ALS mouse model. The work will be of broad interest to researchers and medical biologists to develop new strategies for the treatment of neurodegenerative disorders resulting from denervated skeletal muscles.
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