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A MILD PHENOTYPE ASSOCIATED WITH KCNQ1 P.V205M MEDIATED LONG QT SYNDROME IN FIRST NATIONS CHILDREN OF NORTHERN BRITISH COLUMBIA: EFFECT OF ADDITIONAL VARIANTS AND CONSIDERATIONS FOR MANAGEMENT
BACKGROUND Congenital Long QT Syndrome (LQTS) is common in a First Nations community in Northern British Columbia due to the founder variant KCNQ1 p.V205M. Although well characterized molecularly and clinically in adults, no data have been previously reported on children. Sex differences in cardiac events have been shown in adults, with women of childbearing years demonstrating the highest risk.
Transcending False Nonprofit Governance Dilemmas
Abstract Demands for Broadened Accountability (BA) of nonprofit organizations require that boards achieve a high level of engagement to address important issues properly (Morrison & Salipante, 2007). This paper presents the theoretical basis for boards falling short of such engagement and specifies fundamental obstacles leaders face in achieving BA. One set of especially salient obstacles is conceptualized as false governance dilemmas. Two are considered in this paper: legitimacy vs.
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