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J. Brady

As seen in: Nature, Wiley Online Library, Biomed Central (BMC), Clinical Oncology
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Articles by J. Brady

Monitoring treatment response using an ultra-sensitive ctDNA assay in advanced esophagogastric cancer patients

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By Andrew Nixon Verified, Fabio Navarro, Katherine Zhou, Charles Abbott, Lee McDaniel, Lauren Howard, J. Brady, Donna Niedzwiecki, John Strickler, Sean Boyle, Richard Chen, Hope E. Uronis, Neeraja Ravi, Yingmiao Liu, Jingquan Jia
| Nature Verified
Abstract To explore whether ultra-sensitive circulating tumor DNA (ctDNA) profiling enables earlier prediction of treatment response and detection of disease progression, we applied NeXT Personal, an ultra-sensitive bespoke tumor-informed liquid biopsy platform, to profile tumor samples from the KeyLargo study, a phase II trial in which metastatic esophagogastric cancer (mEGC) patients received capecitabine, oxaliplatin, and pembrolizumab.
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Developing CAR‐T‐sparing Radiotherapy ‐ early dosimetric results

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By J. Brady, N. G. Mikhaeel, G. Ntentas, S. Sivabalasingham
| Wiley Online Library Verified
Background/objective: Radiotherapy (RT) is an effective treatment for residual lymphoma following CD19 chimeric antigen receptor T-cell (CAR-T) therapy. However, there are concerns regarding the potential effect of RT on CAR-T, particularly early after infusion. We initiated a prospective protocol to explore the effect of different RT planning parameters and techniques on dose to the blood, and thus CAR-T cells, in order to develop a “CAR-T sparing RT” for early RT after CAR-T therapy.
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The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review - Critical Care

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By J. Brady, Departament de Medicina
| Biomed Central (BMC)
References Papoutsi E, Giannakoulis VG, Xourgia E, et al. Effect of timing of intubation on clinical outcomes of critically ill patients with COVID-19: a systematic review and meta-analysis of non-randomized cohort studies. Crit Care. 2021;25(1):121. Article PubMed PubMed Central Google Scholar Rochwerg B, Granton D, Wang DX, et al. High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med.
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Response Rates to Newly Implemented Neoadjuvant TCHP Chemotherapy in the Dorset Cancer Network

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By M. Noble, J. Brady
| Clinical Oncology Verified
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Purpose: The neoadjuvant chemotherapy regimen: docetaxel, carboplatin, trastuzumab and pertuzumab (TCHP) was first introduced to the Dorset Cancer Network (Royal Bournemouth County Hospital, Dorset County Hospital and Poole Hospital Foundation Trust) formulary in January 2017.
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