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J. E. Garbarino on Muck Rack

J. E. Garbarino

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Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway

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By A. H. Mitchell, L. J. Bugaj, A. J. Sabnis, J. E. Garbarino
| Science Magazine Verified
Defects in cellular signaling pathways, like those in some cancer cells, are often thought to result in increased or decreased steady-state signals that promote or inhibit cell proliferation. But Bugaj et al. show that dynamic changes in the duration or frequency of a signal can also alter cellular responses (see the Perspective by Kolch and Kiel).
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