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J. Hudson Barnett

As seen in: Nature
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Coordinated response of vascular and glial cells in a pig model of sepsis

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By Kimberly Olney, Kennedi T. Todd, Camila de Ávila, Piyush Hota, Pinar Durgun, Michael Serhan, Ran Wang, Mary Lind, Erica Forzani, Naomi Gades, Leslie Thomas, John D. Fryer, J. Hudson Barnett, Lauren E. Tallant, Katelin Gibson, Adithya Shyamala Pandian
| Nature Verified
Abstract Sepsis is a deadly syndrome arising from overactivation of the immune system in response to a pathogen. Severe sepsis can result in sepsis-associated encephalopathy (SAE) that significantly contributes to morbidity and long-term cognitive impairment. Studying the molecular underpinnings of SAE in the human brain is challenging, and rodent models have limited translational applicability due to significant neuroanatomical and immune differences.
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