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Articles by Jack Bowden
Comical defending
Commentating on our 6-1 victory in Azerbaijan the other week, Ally McCoist described the Qarabag defending as so comical, it should have been accompanied by the Benny Hill music (The tune to which he was referring is ‘Yakety-Sax’, played in the saucy chase scenes on the Benny Hill shows back in the 1970s) It got me thinking about comedy defending. Personally, it’s never a laughing matter when the Toon let a goal in, or the ball is already in the back of our net.
A tribute to Ando
It is Saturday October 29th 1983…Once again, a John Anderson sliding tackle takes Man City’s Scottish left winger Jim Tolmie over the touchline and onto the cinder track. No wonder the victim looks concussed. I had a season ticket in the old iron shed that was the West Stand in those days. In the seats around me ‘Ando’ was known as ‘The Fridge’.
Micky Burns, Aston Villa fans and John McNamee…
I couldn’t help but laugh when, near the end of the game against Aston Villa, the Newcastle United fans were singing: “They’re here, they’re there, they’re every f…ing where, empty seats, empty seats” I’m old enough to remember a song being sung to the same tune in the Leazes End about centre half John McNamee – ‘Big Mac’. He played for Newcastle United between 1966 and 1971 and he was a cult figure, the most brutal of stoppers.
Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditions - Communications Medicine
Abstract Multimorbidity, the co-occurrence of multiple long-term conditions (LTCs), is an increasingly important clinical problem, but little is known about the underlying causes.
Instrumental Variable Methods to Target Hypothetical Estimands With Longitudinal Repeated Measures Data: Application to the STEP 1 Trial
1 Introduction The growing prevalence of obesity is recognized as one of the most serious health issues of the 21st century. A healthy lifestyle, encompassing a balanced diet and sufficient physical exercise, is a key pillar of the weight management puzzle [1], but many socioeconomic and cultural factors, existing comorbidities and even an individual's genetics [2, 3] make this a much harder prospect for some people than others.
A nuclear powered Australia?
With a raft of Commonwealth and state-based legislation banning nuclear power and its associated activities, the Federal Opposition's plans for a nuclear future would require a complex regulatory overhaul.
Co-location and hybrid projects to be a key part of the energy transition
Co-located or "hybrid" projects combining generation and energy storage assets have many benefits. These include providing greater system reliability, unlocking the value of curtailed energy and providing a firmer generation profile to the market, reducing reliance on coal and gas for firming and potentially delivering higher revenues to developers. It is perhaps for these reasons that that we are seeing an increasing number of hybrid projects under development.
Exploring and accounting for genetically driven effect heterogeneity in Mendelian Randomization
The authors have declared no competing interest. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and A.J. and J.B. will serve as guarantors for the contents of this paper. Genotyping of the ALSPAC maternal samples were funded by the Wellcome Trust (WT088806).
SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Association between circadian physical activity patterns and mortality in the UK Biobank - International Journal of Behavioral Nutrition and Physical Activity
The UK Biobank (UKB) is a prospective cohort study of > 500,000 UK participants aged 40–69 years when recruited between 2006–2010. The study collected data on sociodemographic and lifestyle factors, and extensive phenotypic information. The assessment visit included a touchscreen questionnaire, interviews, physical and functional measurements, and the collection of biologic samples. The UKB obtained ethics approval from the North West Multi-Centre Research Ethics Committee.
Sparse dimensionality reduction approaches in Mendelian randomization with highly correlated exposures
Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript published April 19, 2023 (This version) Accepted April 18, 2023 Received May 6, 2022 Share this article Cite this article Sparse dimensionality reduction approaches in Mendelian randomization with highly correlated exposures eLife 12:e80063.
Incorporating discovery and replication GWAS into summary data Mendelian randomization studies: A review of current methods and a simple, general and powerful alternative
New Results doi: https://doi.org/10.1101/2023.01.12.523708 Abstract Mendelian Randomization (MR) is a popular method for using genetics to estimate the causal effect of a modifiable exposure on a health outcome. Single Nucleotide Polymorphisms (SNPs) are typically selected for inclusion if they pass a genome-wide significance threshold in order to guarantee that they are strong genetic instruments, but this also induces Winner's curse, as SNP-exposure associations tend to be overestimated.
Realising the full potential of MR-PHeWAS in cancer
Summary MR-PHeWAS is a powerful new design for discovering causal mechanisms between a disease and its many candidate risk factors in a hypothesis-free manner. This technique has great potential in the field of cancer research, provided that both powerful and principled statistical approaches are used. Main It has long been known that our genes can influence, in a very small way, many aspects of our health and behaviour at a population level.
Mendelian randomisation analysis of the effect of educational attainment and cognitive ability on smoking behaviour
Abstract Recent analyses have shown educational attainment to be associated with a number of health outcomes. This association may, in part, be due to an effect of educational attainment on smoking behaviour. In this study, we apply a multivariable Mendelian randomisation design to determine whether the effect of educational attainment on smoking behaviour is due to educational attainment or general cognitive ability.
Boomtown Fair news: The world is waking… A new story is unfolding… These incredible artists wil
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Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking
Adiposity-Mortality Relationships in Type 2 Diabetes, Coronary Heart Disease, and Cancer Subgroups in the UK Biobank, and Their Modification by Smoking David A. Jenkins, Jack Bowden, Heather A. Robinson, Naveed Sattar, Ruth J.F. Loos, Martin K. Rutter, Matthew Sperrin Diabetes Care Sep 2018, 41 (9) 1878-1886; DOI: 10.2337/dc17-2508
Defending the Coat of Arms of the College
Ever since the College of William and Mary launched its branding crusade to remove the Coat of Arms from just about everywhere possible a few years ago, my heart has been left feeling increasingly conflicted every day. What was so wrong with it that a decision was made to stamp it out from usage almost everywhere across campus, and is it understood why our coat of arms is still important to the College community?
Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study
Investigating causality in associations between education and smoking: A two-sample Mendelian randomization study Suzanne H. Gage, Jack Bowden, George Davey Smith, Marcus R. Munafo bioRxiv 184218; doi: https://doi.org/10.1101/184218
Weighing Evidence “Steampunk” Style via the Meta-Analyser
Meta-analysis is the science of combining the evidence available from different sources to arrive at the most sensible and informed conclusion to a given question. The technique has a long history in medical research, where it is routinely used to aggregate results from independent clinical trials testing competing therapies (e.g., which is better: treatment A or B? And by how much?).
I recommend ....
I recommend ... Jack Bowden Posted: Wednesday, November 23, 2016 3:28 am I recommend .... By Jack Bowden Buffalo Reflex - Buffalo, Missouri | 0 comments I highly recommend the first Friday music jam at the Leaky Roof Meadery, where people of all musical skill levels bring their acoustic instruments and play and sing together for hours. This kind of musical gathering is the very reason I started playing music in the first place. An online service is needed to view this article in its entirety.
Weighing Evidence “Steampunk” Style via the Meta-Analyser
Meta-analysis is the science of combining the evidence available from different sources to arrive at the most sensible and informed conclusion to a given question. The technique has a long history in medical research, where it is routinely used to aggregate results from independent clinical trials testing competing therapies (e.g., which is better: treatment A or B? And by how much?).
Weighing Evidence “Steampunk” Style via the Meta-Analyser
Meta-analysis is the science of combining the evidence available from different sources to arrive at the most sensible and informed conclusion to a given question. The technique has a long history in medical research, where it is routinely used to aggregate results from independent clinical trials testing competing therapies (e.g., which is better: treatment A or B? And by how much?).
Response to Hartwig and Davies
Thank you for the opportunity to respond to the thoughtful and timely letter by Hartwig and Davies.1 They do indeed raise a very important practical issue with the implementation of MR-Egger regression in the single-sample setting, or with the use of so called `internal’ weights, namely weak instrument bias.
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
Background: MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and provides an estimate of the causal effect adjusted for its presence.
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