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Articles

Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development

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By David A Figge, Jack Crim, Rita M. Cowell, David G. Standaert
| JNeurosci Verified
Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development David A. Figge, Henrique de Amaral Oliveira, Jack Crim, Rita M. Cowell, David G. Standaert, Karen L. Eskow Jaunarajs Journal of Neuroscience 26 June 2024, 44 (26) e0050242024; DOI: 10.1523/JNEUROSCI.0050-24.2024
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Differential activation states of direct pathway striatal output neurons during L-DOPA-induced dyskinesia development.

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By David A Figge, Jack Crim, Rita M. Cowell, David G. Standaert
| JNeurosci Verified
Differential activation states of direct pathway striatal output neurons during L-DOPA-induced dyskinesia development. David A. Figge, Henrique de Amaral Oliveira, Jack Crim, Rita M. Cowell, David G. Standaert, Karen L. Eskow Jaunarajs Journal of Neuroscience 25 April 2024, e0050242024; DOI: 10.1523/JNEUROSCI.0050-24.2024
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Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia.

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By Jack Crim, Rita M. Cowell, David G. Standaert, David A Figge
| BioRxiv
Abstract L-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). The emergence of LID is linked to heightened sensitivity of striatal dopaminergic signaling and driven by abnormal fluctuations in synaptic dopamine levels following each administration of L-DOPA.
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