Jack George Morikka on Muck Rack

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Articles

Toxicogenomic Assessment of In Vitro Macrophages Exposed to Profibrotic Challenge.

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By Jack George Morikka, Antonio Federico, Lena Möbus, Simo Inkala
| biorxiv.org
Abstract Immune signalling is a crucial component in the progression of fibrosis. However, approaches for safety assessment of profibrotic substances, providing information on mechanistic immune responses, are underdeveloped. This study utilises a comprehensive analysis of RNA sequencing data from macrophages exposed in vitro to multiple sublethal concentrations of the profibrotic agent bleomycin, over multiple timepoints.
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Methylation and Transcriptomic Profiling Reveals Short Term and Long Term Regulatory Responses in Polarized Macrophages

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By Giorgia Migliaccio, Giusy del Giudice, Jack George Morikka, Maaret Vaani
| biorxiv.org
Abstract Macrophage plasticity allows adoption of distinct functional states in response to environmental cues. While unique transcriptomic profiles define these states, focusing solely on transcription neglects potential long-term effects. The investigation of epigenetic changes can be used to understand how temporary stimuli can result in lasting effects.
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