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Jackelien van Scheppingen

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Articles

Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro

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By Amsterdam UMC, Jackelien van Scheppingen, Jasper Anink, Diede W.M. Broekaart
| Color Research & Application Verified
Original Article Increased matrix metalloproteinases expression in tuberous sclerosis complex: modulation by microRNA 146a and 147b in vitro Laura Wierts Brendinn Therapeutics, Amsterdam, the Netherlands Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, De Boelelaan, 1117 Amsterdam, the Netherlands Search for more papers by this author Eleonora Aronica Corresponding Author E-mail address: e.aronica@amc.uva.nl Amsterdam...
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Novel Histopathological Patterns in Cortical Tubers of Epilepsy Surgery Patients with Tuberous Sclerosis Complex

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By Anand Iyer, Angelika Mühlebner, Jackelien van Scheppingen, Hanna M. Hulshof, Theresa Scholl
| PLOS
Tuberous Sclerosis Complex (TSC) is a genetic hamartoma syndrome frequently associated with severe intractable epilepsy. In some TSC patients epilepsy surgery is a promising treatment option provided that the epileptogenic zone can be precisely delineated. TSC brain lesions (cortical tubers) contain dysmorphic neurons, brightly eosinophilic giant cells and white matter alterations in various proportions. However, a histological classification system has not been established for tubers.
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