Jacob Bellamy

On 4 February 2026, significant amendments to the Takeover Code came into effect, addressing three areas: dual class share structures, IPO disclosures, and share buybacks. This article summarises the key changes. Since April 2024, the UK Listing Rules have permitted companies with dual class share structures (“DCSS”) to list on UK markets.

Abstract About 50% of poor prognosis neuroblastoma arises due to MYCN over-expression. We previously demonstrated that MYCN and PRMT5 proteins interact and PRMT5 knockdown led to apoptosis of MYCN amplified (MNA) neuroblastoma. Here we evaluate PRMT5 inhibitors GSK3203591/GSK3326593 as targeted therapeutics for MNA neuroblastoma and show MYCN-dependent growth inhibition and apoptosis.