Jacob Lercke Skytte on Muck Rack

Jacob Lercke Skytte

As seen in: Nature
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Articles

Whole-organ spatial transcriptional analysis at cellular resolution using TRISCO

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By YUE LI, Judith C. Kreutzmann, Ilse Eidhof, Jacob Lercke Skytte, Urmas Roostalu, Jacob Hecksher-Sørensen, Shigeaki Kanatani, Per Uhlén, Lea Lydolph Larsen, Casper Gravesen Salinas
| Nature Verified
Abstract The emerging field of 3D histology centers on the molecular profiling of intact organs for a comprehensive understanding of biological systems. While current methods focus largely on protein visualization, techniques for whole-organ RNA transcript imaging remain underdeveloped.
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Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R - Nature Communications

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By Camilla Lund, Pablo Ranea-Robles, Sarah Falk, Dylan M. Rausch, Urmas Roostalu, Jens Friis Lund, Nathalie Krauth, Jacob Lercke Skytte
| Nature Verified
Abstract Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain. Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and prolonged inhibition of voluntary food intake following overfeeding-induced weight gain. We reveal that FGF21 is dispensable for this defense against weight gain. Targeted proteomics unveiled novel circulating factors linked to overfeeding, including the protease  legumain (LGMN).
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