Jacob Massey on Muck Rack

Jacob Massey

As seen in: Nature, Great Yarmouth Mercury, North Norfolk News, Lowestoft Journal, Beccles & Bungay Journal, Dereham Times, Diss Mercury, Fakenham & Wells Times, Thetford & Brandon Times, Wymondham and Attleborough Mercury and
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Articles

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration - Nature Communications

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By Megha Jhanji, Jacob Massey, C. Dirk Keene, Tao Ma, Mathew Sajish, Chintada Nageswara Rao, Michael D. Wyatt
| Nature Verified
Abstract Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We previously showed that tyrosine inhibits tyrosyl-tRNA synthetase (TyrRS)-mediated activation of poly-ADP-ribose polymerase 1 (PARP1). Here, we show that histone serine-ADP-ribosylation is decreased in Alzheimer’s Disease (AD) brains, and increased tyrosine levels deplete TyrRS and cause neuronal DNA damage.
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Thousands raised through Beccles Cycle for Life

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By Jacob Massey
| enjoybecclesmore.co.uk
Hundreds of cyclists of all ages and abilities have taken to their bikes for a popular annual fundraising ride. Beccles Cycle for Life peddled into its 17th year on Sunday morning, with around 250 cyclists riding a variety of routes. The event is organised by the Rotary Club of Beccles and the proceeds of the ride are split evenly between the East Anglian Air Ambulance and the club’s charitable trust.
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