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Articles

Characterization of erythroferrone oligomerization and its impact on BMP antagonism

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By jacob mast, Edmund Leach, Thomas Thompson
| BioRxiv
Abstract Hepcidin, a peptide hormone that negatively regulates iron metabolism, is expressed by bone morphogenetic protein (BMP) signaling. Erythroferrone (ERFE) is an extracellular protein that binds and inhibits BMP ligands, thus positively regulating iron import by indirectly suppressing hepcidin. This allows for rapid erythrocyte regeneration after blood loss.
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