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Stereospecific Access to α-Haloalkyl Esters via Enol Ester Epoxides and Synthesis of a C3-C21 Fragment of Bastimolide A
Stereospecific Access to α-Haloalkyl Esters via Enol Ester Epoxides and Synthesis of a C3–C21 Fragment of Bastimolide A We report a 14-step synthesis of a C3–C21 fragment of bastimolides A and B, antimalarial macrocyclic polyketides. A crucial ring-opening reaction of an enol ester epoxide showed previously unexplored reactivity, leading to an asymmetric synthesis of α-haloalkyl esters.
A Three-Step Catalytic Asymmetric Sequence from Alkynes to α-Silyloxyaldehydes and Its Application to a C22-C41 Fragment of Bastimolide A
Download Hi-Res ImageDownload to MS-PowerPointCite This:Org. Lett. 2024, XXXX, XXX RETURN TO ARTICLES ASAPPREVLetterNEXT Jacob N. Hackbarth Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States and * Cite this: Org. Lett. 2024, XXXX, XXX rapid-communication ACS Publications.
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