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Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism
The treatment and control of Plasmodium vivax malaria are complicated by a latent, undetectable liver-stage form in the parasite life cycle, known as the hypnozoite [1,2]. Hypnozoites can cause clinical relapses weeks to months after clearance of the acute blood-stage infection. This can increase the disease burden and the potential for unexpected transmission, as well as impede efforts to eliminate vivax malaria [3,4].
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?
Background— Although the inverse association between high-density lipoprotein cholesterol (HDL-C) and risk of cardiovascular disease (CVD) has been long established, it remains unclear whether low HDL-C remains a CVD risk factor when levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) are not elevated. This is a timely issue because recent studies have questioned whether HDL-C is truly an independent predictor of CVD.
Sex‐Specific Parental Effects on Offspring Lipid Levels
Methods and Results In this study, we analyzed the role of parental levels of total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), and triglycerides (TGs) in explaining the values of the corresponding traits in adult offspring.
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