Jacques Christopher Jaar on Muck Rack

Jacques Christopher Jaar

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Articles

Diabetes exacerbates experimental peri-implantitis in mice with elevated IL-17A-associated inflammation and IL-17F upregulation

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By Tsute Chen, Guoqin Cao, Nanako Kuriki, Elaheh Dalir Abdolahinia, Satoru Shindo, Shohei Yamashita, Sunniva Ruiz, Avissasadat meraji, Alex Albu, Motoki Okamoto, Xuesong He, Saynur Vardar, Maiko Suzuki, Jiang Lin, Toshihisa Kawai, Xiaozhe Han, Takumi Memida, Jacques Christopher Jaar
| Nature Verified
Abstract This study investigated the role of interleukin-17 (IL-17) and the oral microbiome in peri-implant inflammation and bone loss under hyperglycemic and normoglycemic conditions. Wild-type (WT) and diabetic (db/db) mice with maxillary implants underwent ligature placement with or without IL-17A neutralization. Bone loss, osteoclast activity, inflammatory cytokines, Th17/Treg balance, and expression of IL-17Family members were analyzed.
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