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Jadyn R Malone

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Articles

The Use of Dansyl Chloride to Probe Protein Structure and Dynamics

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By James Larson, Monika Tokmina-Lukaszewska, Jadyn R Malone, Ethan J. Hasenoehrl
| MDPI
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Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions

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By Alex J. Guseman, Angela M. Gronenborn, Sara Volz, Jadyn R Malone
| biorxiv.org
Abstract Human γD-crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual's entire lifetime to avoid aggregation and protein deposition-associated cataract formation. γD-crystallin contains two homologous domains, an N-terminal domain (NTD) and a C-terminal domain (CTD), which interact via a hydrophobic interface.
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