Jae-Su Moon

Editor’s summary Abberant hepatic macrophage activity has been implicated in NASH development, but the mechanism of this immune dysregulation is unclear. Jeelani et al. show that a hypoxia-inducible factor, HIF-2α, promotes differential effects on macrophage subpopulations during NASH in obesity.

Cyclo(L-Phe-L-Pro) (cFP) and Phe-Pro were purchased from Bachem (Bubendorf, Switzerland) and Sigma-Aldrich (St. Louis, MO, USA), respectively. Other cyclic dipeptides including biotinylated cFP and IAEDANS-labeled cFP were synthesized in-house at Sogang University, Seoul Korea. An anti-norovirus reagent 17-DMAG58, E. coli (O26:B6) lipopolysaccharide (LPS), and polyinosinic:polycytidylic acid, a double-stranded RNA analog (cat no. I3036; S-poly(I:C), Supplementary Fig.