Jaebong Kim

Abstract Multiciliated cells generate numerous centrioles to support motile cilia essential for fluid flow. This process was thought to rely on the deuterosome, a DEUP1-dependent structure. Here, we show that DEUP1 plays a critical role in the basal foot (BF)—an asymmetric appendage of the basal body required for coordinated ciliary beating. Using high-resolution imaging, we localize DEUP1 to the middle tier of the BF, adjacent to CNTRL.

Abstract The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 degradation, cytoplasmic retention and inhibition of Bmp/Smad1 signaling. While Fgf/Erk pathway has been documented to inhibit Bmp/Smad1 signaling, several studies also suggests the cooperative interaction between these two pathways in different context.

Abstract The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 degradation, cytoplasmic retention and inhibition of Bmp/Smad1 signaling. While Fgf/Erk pathway has been documented to inhibit Bmp/Smad1 signaling, several studies also suggests the cooperative interaction between these two pathways in different context.