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Jaejoon Lim

As seen in: Color Research & Application, Nature

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Articles

The epidermal growth factor receptor variant type III mutation frequently found in gliomas induces astrogenesis in human cerebral organoids

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By Jaejoon Lim, Hyun‐Mun Kim, Sang‐Hyeok Lee, Jongman Yoo
| Color Research & Application Verified
1 INTRODUCTION A growing body of evidence suggests that tumorigenesis is closely linked to developmental processes. Therefore, study of the function of tumour drivers (ie, gene mutations) in the setting of developmental biology may help us to better understand the process of tumorigenesis.1, 2 Brain tumours are generally classified into glioma and non‐glioma.
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Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients

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By Jaejoon Lim, Min Kim, YoungJoon Park, Ju Won Ahn
| Nature Verified
Abstract Inflammation in tumor microenvironments is implicated in the pathogenesis of tumor development. In particular, inflammasomes, which modulate innate immune functions, are linked to tumor growth and anticancer responses. However, the role of the NLRC4 inflammasome in gliomas remains unclear. Here, we investigated whether the upregulation of the NLRC4 inflammasome is associated with the clinical prognosis of gliomas.
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