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Jaemyeong Jeon

As seen in: Frontiers
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Articles

Systemic removal of host restriction factors enables rapid, scalable virus production for cell culture-based vaccine development

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By Youngki Shin, Zhengmei Xu, Jaemyeong Jeon, Jinsoo Oh
| Frontiers
Abstract The efficiency of cell culture-based vaccine production is fundamentally constrained by the antiviral defenses of host cells, creating a major bottleneck for rapid and large-scale vaccine manufacturing. Key antiviral proteins-such as RNase L, PKR, and JAK1 act as intrinsic brakes on viral replication, limiting efficient propagation of many clinically relevant viruses.
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