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Jaffna Mathiaparanam on Muck Rack

Jaffna Mathiaparanam

As seen in: BioRxiv
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Articles

Serotonin neuromodulation directs optic nerve regeneration

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By Melissa Baxter, Michael Granato, Kristian Saied-Santiago, Jaffna Mathiaparanam
| BioRxiv
Abstract Optic nerve (ON) regeneration in mammalian systems is limited by an overshadowing dominance of inhibitory factors. This has severely hampered the identification of pro-regenerative pathways. Here, we take advantage of the regenerative capacity of larval zebrafish to identify pathways that promote ON regeneration. From a small molecule screen, we identified modulators of serotonin (5-HT) signaling that inhibit ON regeneration.
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