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Expression of Transmembrane Glycoprotein TROP2 in Triple-Negative Breast Cancer and It’s Potential as a Molecular Classifier for Targeted Therapy

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By Roshni Saravanan, Vaishnavi Balasubramanian, Jagadeesh Naidu, Nivetha Balasubramanian
| Taylor & Francis Online
Abstract Trophoblast Cell-surface antigen 2 (TROP2), a calcium signal transducer & a transmembrane glycoprotein expression was studied in Triple-Negative Breast Cancer (TNBC) patients. mRNA expression, immunohistochemical and immunofluorescence analysis illustrated a higher TROP2 expression in the TNBC tissues. Assessment of tumor-infiltrating lymphocytes in TNBC samples was done and in silico studies depicted a significant association between TROP2 expression and infiltration of CD4+ cells.
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