James Barker

1 Introduction The generally high-dimensional nature of the electronic Schrödinger equation renders it inaccessible to conventional numerical techniques. Some recourse is possible to the specialized mechanisms of computational quantum chemistry [1-5], but the involved costs still scale superlinearly, so these cannot be applied to larger molecular systems, especially not to an acceptable level of accuracy. A common tactic is to decompose the single overarching electronic problem into subproblems.

Abstract Cerebral amyloid angiopathy (CAA) is a disease with several clinical manifestations. It is characterised by amyloid-beta deposition in cerebral blood vessels, making them prone to bleeding. The incidence of CAA increases with age and may be associated or co-exist with intraparenchymal neurodegenerative proteinopathies, which makes it an increasingly relevant condition for adult physicians in all areas of medical practice.