James N. Baraniuk

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2. Results 2.1. RdRp Motifs The “common core” for the active site of ss(+)RNA virus RdRps is defined by structural motifs A to G []. Motifs A, B and C form the palm of the right-handed structure with motif F in the fingers ( and ). Motifs D and E in the palm and G in the fingers are positioned in approximately the same three-dimensional space across species but cannot be exactly superimposed (B). The thumb does not contribute to the active site.

Introduction Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease affecting ∼20 million worldwide. It can be triggered by infection, traumatic life events, chemicals, toxins, immunizations, anesthetics, physical trauma, among others (Chu et al., 2019).