James Olukayode Olopade

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1. Introduction The synthesis and assembly of N-methyl-D-aspartate receptor (NMDAR) subunits occur in the rough endoplasmic reticulum (RER), after which they are conveyed to the dendrites by vesicles where insertion into the spines takes place []. They are proportioned into three different pools, based on their activities: i. synaptic pool; ii. extrasynaptic pool; and iii. non-synaptic pool (cell bodies and dendrites containing NMDARs) [].