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James Watkins

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James Watkins, Author at The Living Church

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By James Watkins
| The Living Church Verified
James Watkins, PhD is a Guest Writer. He is Associate Dean of Academic Affairs and Affiliate Professor of Theological Aesthetics at Nashotah House Theological Seminary. His published work includes Creativity as Sacrifice: Toward a Theological Model for Creativity in the Arts (Fortress Press, 2015). He is co-editor with Anthony Bolos and J. Richard Middleton of the forthcoming What Is Christianity? An Introduction (Routledge).
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Assessing the Suitability of Deubiquitylases As Substrates For Targeted Protein Degradation

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By Joel Tong, James Watkins
| BioRxiv
Abstract The development of selective inhibitors of Deubiquitylase enzymes (DUBs) is difficult due to a high level of homology in the active sites of the ≈ 100 such enzymes in the human proteome. A potential way to achieve this in a more facile manner would be to develop PROTACs or molecular glues that engage the target DUB in a less conserved region outside of the catalytic domain. However, this raises the concern that auto-deubiquitylation would make DUBs poor substrates for this modality.
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Brenda Blethyn and Andrea Riseborough are stellar in a drama with a sting in its tail

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By Phil De Semlyen Verified, Andrea Riseborough, James Watkins, Brenda Blethyn
| Time Out Verified
Two semi-detached bungalows with a shared partition, a dog, and a couple of Oscar nominees at the top of their formidable games: Paul Andrew Williams’s pared-back and bruising three-hander is a realist drama with deep undercurrents that whirlpool into a denouement you will not see coming.
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