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Jamie Antelo Rivero on Muck Rack

Jamie Antelo Rivero

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HO-1 and NLRP3-associated lung dysfunction and systemic inflammation in a noninfectious COVID-19 spike protein murine model

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By Sophia Kwon, Joanna Zhou, Arul Veerappan, Mengling Liu, Gabriele Grünig, George Crowley, Anna Nolan, Jamie Antelo Rivero, Hailey Bernier
| Nature Verified
Abstract The COVID-19 (C19) pandemic caused significant mortality often due to lung injury and systemic inflammation, but there is significant heterogeneity in severity, and the pathobiology is not well understood. We examined C19-induced pulmonary and inflammatory sequelae using a murine noninfectious model to further define the model’s utility and to also understand the role of mediators such as heme oxgenase-1 (HO-1).
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