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Jamison Timothy F on Muck Rack

Jamison Timothy F

As seen in: ACS Publications
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Synthesis of Dolutegravir Exploiting Continuous Flow Chemistry

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By Paul Watts, Sinazo Nqeketo, Ziegler Robert E, Jamison Timothy F
| ACS Publications
Abstract An efficient continuous flow process for the synthesis of dolutegravir, an active pharmaceutical ingredient (API) for HIV treatment, was investigated. The synthetic procedure starts from a readily available benzyl-protected pyran via six chemical transformations using continuous flow reactors. The significant advantage of this flow process includes the reduction of the overall reaction time from 34.5 h in batch to 14.5 min.
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