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Jan Peter Heinen on Muck Rack

Jan Peter Heinen

Breda
As seen in: Science Magazine, BioRxiv, Strategic Finance
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Articles

The Drosophila cancer-germline, head-to-head gene pair TrxT and dhd is dispensable for normal brain development but plays a major role in l(3)malignant brain tumour growth.

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By Cristina Molnar, Jan Peter Heinen, Jose Reina, José Juan Reina, Salud Llamazares
| BioRxiv
Abstract Drosophila thioredoxins Deadhead (Dhd) and Thioredoxin-T (TrxT) are encoded by a head-to-head gene pair in the X chromosome. Akin to human cancer-germline (CG) genes, dhd and TrxT expression is normally sex and germline specific, but becomes upregulated in brain tumours of either sex caused by mutation in l(3)malignant brain tumour (l(3)mbt).
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Managing Digital Transformation

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By Frank Verbeeten, Jan Peter Heinen
| Strategic Finance Verified
Business leaders around the world are being called to drive digital strategy. To better understand the impact of this digital transformation on the finance function, we investigated the various approaches of some CFOs: the degree of digital transformation, the involvement of finance in that digital transformation, and the challenges finance teams face on the digital journey.
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The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila

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By IRB Barcelona, Cristina Molnar, Jan Peter Heinen, Jose Reina
| Science Magazine Verified
Abstract The notable male predominance across many human cancer types remains unexplained. Here, we show that Drosophila l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7).
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