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Jan Pilch

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Articles by Jan Pilch

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms

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By Lorenz Thurner, Natalie Fadle, Bernhard Thurner, Moritz Bewarder, Evi Regitz, Vadim Lesan, Torben M. Rixecker, Klaus-Dieter Preuss, Claudia Schormann, Dominic Kaddu-Mulindwa, Klaus Roemer, Onur Çetin, Sebastian Mang, Andre Becker, Frederik Seiler, Christian Herr, Johannes Lehmann, Andreas Link, Christian Werner, Patrick Wuchter, Sixten Körper, Thorsten Pfuhl, Stefan Lohse, Jürgen Rissland, Cihan Papan, Sophie Roth, Patricia Wagner, Martin Witzenrath, Charlotte Thibeault, Sina M. Pütz, Jens-Peter Reese, Michael Krawczak, Eckard Hamelmann, Verena Kopfnagel, Dana Stahl, Sabine Hanß, Sabine Ameling, Uwe Völker, Stefan Hansch, Marcus Dörr, Sabine Blaschke, Edgar Dahl, Daniel W Pape, Astrid Petersmann, Stephan Stilgenbauer, Frank Bloos, Hubert Schrezenmeier, Frank Langer, Gereon Gäbelein, Jochen Pfeifer, Michael Bauer, Frank Neumann, Michael Bohm, Gabriele Anton, Carsten Kuenne, Soni Savai Pullamsetti, Mario Looso, Robert Bals, Sigrun Smola, Patrick Meybohm, Marcin Krawczyk, Philipp M. Lepper, Christoph Kessel, Birgit Bette, Yvan Fischer, Marie-Christin Hoffmann, Christian Lensch, Angela Thiel-Bodenstaff, Katrin Thieser, Jan Pilch, J. Janne Vehreschild, Margarete Scherer, Isabel Bröhl, Ira an Haack, Lazar Mitrov, Karin Fiedler, Ramsia Geisler, Heike Valentin, Josephine Braunsteiner, Bettina Friesenhahn-Ochs, Sören Leif Becker
| Nature Verified
Abstract SARS-CoV-2 infection affects multiple immune mechanisms and leads to severe COVID-19 and death, in part related to infection-induced or pre-existing autoantibodies. Here, we describe severe COVID-19 to associate with autoantibodies against interleukin-1 receptor antagonist (IL-1Ra) and progranulin (PGRN), endogenous antagonists of IL-1 and TNF signaling, respectively.
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