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Soni Savai Pullamsetti on Muck Rack

Soni Savai Pullamsetti

As seen in: Nature, MDPI, Science Magazine, Cell Metabolism, Cell Press, European Respiratory Journal, International Journal of Cardiology
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Articles

IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition

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By Siavash Mansouri, Golnaz Hesami, Anoop T. Ambikan, Annika Karger, Stephan Klatt, Ujjwal Neogi, Konda Babu Kurakula, Blerina Aliraj, Anne Miller, Boryana Petrova, Miloslav Sanda, Evelyn Sirait-Fischer, Stefan Guenther, Carsten Kuenne, Clemens Ruppert, Sven Zukunft, Ingrid Fleming, Arvand Haschemi, Thorsten Stiewe, Friedrich Grimminger, Martin Reck, Andreas Weigert, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai, Ibrahim Alkoudmani, Stefan Gattenlöhner
| Cell Metabolism Verified
Keywords lung cancer tumor-associated macrophages itaconate glucose-6-phosphate dehydrogenase Introduction Lung cancer is the most frequently diagnosed malignant disease worldwide and is associated with the highest mortality rate.1 In recent decades, lung cancer mortality has declined due to reduced smoking, improved detection, and the emergence of immunotherapy.
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Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms

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By Lorenz Thurner, Natalie Fadle, Bernhard Thurner, Moritz Bewarder, Evi Regitz, Vadim Lesan, Torben M. Rixecker, Klaus-Dieter Preuss, Claudia Schormann, Dominic Kaddu-Mulindwa, Klaus Roemer, Onur Çetin, Sebastian Mang, Andre Becker, Frederik Seiler, Christian Herr, Johannes Lehmann, Andreas Link, Christian Werner, Patrick Wuchter, Sixten Körper, Thorsten Pfuhl, Stefan Lohse, Jürgen Rissland, Cihan Papan, Sophie Roth, Patricia Wagner, Martin Witzenrath, Charlotte Thibeault, Sina M. Pütz, Jens-Peter Reese, Michael Krawczak, Eckard Hamelmann, Verena Kopfnagel, Dana Stahl, Sabine Hanß, Sabine Ameling, Uwe Völker, Stefan Hansch, Marcus Dörr, Sabine Blaschke, Edgar Dahl, Daniel W Pape, Astrid Petersmann, Stephan Stilgenbauer, Frank Bloos, Hubert Schrezenmeier, Frank Langer, Gereon Gäbelein, Jochen Pfeifer, Michael Bauer, Frank Neumann, Michael Bohm, Gabriele Anton, Carsten Kuenne, Soni Savai Pullamsetti, Mario Looso, Robert Bals, Sigrun Smola, Patrick Meybohm, Marcin Krawczyk, Philipp M. Lepper, Christoph Kessel, Birgit Bette, Yvan Fischer, Marie-Christin Hoffmann, Christian Lensch, Angela Thiel-Bodenstaff, Katrin Thieser, Jan Pilch, J. Janne Vehreschild, Margarete Scherer, Isabel Bröhl, Ira an Haack, Lazar Mitrov, Karin Fiedler, Ramsia Geisler, Heike Valentin, Josephine Braunsteiner, Bettina Friesenhahn-Ochs, Sören Leif Becker
| Nature Verified
Abstract SARS-CoV-2 infection affects multiple immune mechanisms and leads to severe COVID-19 and death, in part related to infection-induced or pre-existing autoantibodies. Here, we describe severe COVID-19 to associate with autoantibodies against interleukin-1 receptor antagonist (IL-1Ra) and progranulin (PGRN), endogenous antagonists of IL-1 and TNF signaling, respectively.
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Lung tumor immunity: redirecting macrophages through infection-induced inflammation

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By Öznur Aktay-Cetin, Soni Savai Pullamsetti, Susanne Herold, Rajkumar Savai
| Cell Press Verified
Keywords lung tumor lung infection inflammation macrophages immunity tumor microenvironment Non-resolving inflammation: an underlying factor in lung cancer and infections Non-resolving inflammation is a common feature in a wide range of lung disorders, and significantly compromises pulmonary health and function. Among these, lung cancer and lung infections are major contributors to global disease burden.
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