Janet M Yoon

Von Janet Yoon, School of Historical Studies, Institute for Advanced Study The School of Historical Studies at the Institute for Advanced Study supports scholarship in all fields of historical research but is concerned principally with the history of western, near eastern and Asian civilizations, with particular emphasis upon the Greek and Roman world, the history of Europe (medieval, early modern, and modern), the Islamic world, East Asian studies, art history, history of science, and...

1. Introduction Ewing Sarcoma (ES) is the second most common bone cancer in children and young adults with approximately 1.5 cases per million [1,2]. Multimodality therapy incorporating local and systemic treatments has drastically improved 5-year survival of patients with local disease to more than 70% [3]. Despite advances in available treatments, recurrent or metastatic ES carries a poor prognosis with 5-year overall survival estimated at <30% [4,5,6].

Severe neuropathy is a known adverse effect of vincristine in patients with Charcot-Marie-Tooth disease (CMT). We present the case of a 16-year-old girl with anaplastic medulloblastoma treated with gross total resection and high-dose craniospinal radiation with adjuvant vincristine chemotherapy who developed acute-onset severe quadriplegia and vocal cord paralysis. Vincristine and radiation therapy were discontinued.