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Janice Gambardella on Muck Rack

Janice Gambardella

As seen in: Taylor & Francis Online
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Articles

Overcoming target interference in bridging anti-drug antibody (ADA) assay by optimizing sample treatment

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By Sally Ye, Daniel Kim, Janice Gambardella, Lioudmila Zaslavskaia
| Taylor & Francis Online
ABSTRACT Background Drug bridging immunoassays are widely employed as the standard approach for detecting anti-drug antibodies (ADAs) in the development of new biological entities. A major challenge in these assays is mitigating target interference, particularly when the soluble target exists in dimeric forms, which can result in false positive signals and compromise assay specificity.
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